Characterization of the PB2 Cap Binding Domain Accelerates Inhibitor Design
Abstract
X-ray crystallographic structural determinations of the PB2 cap binding domain (PB2cap) have improved the conformational characterization of the RNA-dependent RNA polymerase machinery (PA, PB2, and PB1) of the influenza virus. Geometrically, the catalytic PB1 subunit resembles the palm of a human hand. PA lies near the thumb region, and PB2 lies near the finger region. PB2 binds the cap moiety in the pre-mRNA of the host cell, while the...
Paper Details
Title
Characterization of the PB2 Cap Binding Domain Accelerates Inhibitor Design
Published Date
Jan 28, 2018
Journal
Volume
8
Issue
2
Pages
62 - 62
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