Shedding light on the cell biology of extracellular vesicles

Cells produce a wide variety of extracellular vesicles (subdivided into exosomes and microvesicles), which carry a multitude of cargoes, including proteins, lipids and nucleic acids. These vesicles have emerged as important means of cell–cell communication in physiology and disease, and their use in the clinic is now being explored. Extracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising exosomes and...