Hepatocyte-specific deletion of IL1-RI attenuates liver injury by blocking IL-1 driven autoinflammation

•Hepatocyte-specific deletion of IL-1RI does not produce a spontaneous phenotype. •Loss of IL-1RI in hepatocytes ameliorates D-GalN/LPS-induced liver injury and improves survival. •Inflammatory signal amplification in acute liver failure involves liver-infiltrating neutrophils. •NLRP-3 dependent caspase 1 activation amplifies hepatic inflammation through IL-1RI. Background & Aims Interleukin (IL)-1-type cytokines including IL-1α, IL-1β and...