Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.
Abstract
Partial substitution of CRISPR RNAs with DNA nucleotides retains CRISPR–Cas9 genome editing activity while enhancing efficiency and specificity within cells, suggesting that DNA–RNA hybrids may be economical reagents for targeted genome editing.
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Paper Details
Title
Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.
Published Date
Jan 29, 2018
Journal
Volume
14
Issue
3
Pages
311 - 316
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Notes
History