Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium
Abstract
Botulinum neurotoxins (BoNTs), produced by various Clostridium strains, are a family of potent bacterial toxins and potential bioterrorism agents. Here we report that an Enterococcus faecium strain isolated from cow feces carries a BoNT-like toxin, designated BoNT/En. It cleaves both VAMP2 and SNAP-25, proteins that mediate synaptic vesicle exocytosis in neurons, at sites distinct from known BoNT cleavage sites on these two proteins. Comparative...
Paper Details
Title
Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium
Published Date
Feb 1, 2018
Journal
Volume
23
Issue
2
Pages
169 - 176.e6
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