Progressive Reduction in Gray Matter in Patients with Schizophrenia Assessed with MR Imaging by Using Causal Network Analysis

Purpose To investigate the temporal and causal relationships of structural changes in the brain in patients with schizophrenia. Materials and Methods T1-weighted magnetic resonance (MR) images of 97 patients with schizophrenia (29 women; mean ± standard deviation age, 41 years ± 11.5; range, 16–66 years; illness duration, 16.3 years ± 10.9; range, 0–50 years) and 126 age- and sex-matched (38 years ± 14.9; range, 18–68 years; 42 women) healthy...