Identification of Pre-Existing Adaptive Immunity to Cas9 Proteins in Humans

Pages: 243345
Published: Jan 5, 2018
Abstract
The CRISPR-Cas9 system has proven to be a powerful tool for genome editing allowing for the precise modification of specific DNA sequences within a cell. Many efforts are currently underway to use the CRISPR-Cas9 system for the therapeutic correction of human genetic diseases. The most widely used homologs of the Cas9 protein are derived from the bacteria Staphylococcus aureus (S. aureus) and Streptococcus pyogenes (S. pyogenes). Based on the...
Paper Details
Title
Identification of Pre-Existing Adaptive Immunity to Cas9 Proteins in Humans
Published Date
Jan 5, 2018
Journal
Pages
243345
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