Systematic discovery of antiphage defense systems in the microbial pangenome
Abstract
The arms race between bacteria and phages led to the development of sophisticated antiphage defense systems, including CRISPR-Cas and restriction-modification systems. Evidence suggests that unknown defense systems are located in “defense islands” in microbial genomes. We comprehensively characterized the bacterial defensive arsenal by examining gene families that are clustered next to known defense genes in prokaryotic genomes. Candidate...
Paper Details
Title
Systematic discovery of antiphage defense systems in the microbial pangenome
Published Date
Mar 2, 2018
Journal
Volume
359
Issue
6379
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