Fanconi anaemia and cancer: an intricate relationship
Abstract
Fanconi anaemia (FA) is a genetic disorder that is characterized by bone marrow failure (BMF), developmental abnormalities and predisposition to cancer. Together with other proteins involved in DNA repair processes and cell division, the FA proteins maintain genome homeostasis, and germline mutation of any one of the genes that encode FA proteins causes FA. Monoallelic inactivation of some FA genes, such as FA complementation group D1 (FANCD1;...
Paper Details
Title
Fanconi anaemia and cancer: an intricate relationship
Published Date
Jan 29, 2018
Journal
Volume
18
Issue
3
Pages
168 - 185
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