Aspergillus fumigatus Infection-Induced Neutrophil Recruitment and Location in the Conducting Airway of Immunocompetent, Neutropenic, and Immunosuppressed Mice

Published on Jan 1, 2018in Clinical & Developmental Immunology
· DOI :10.1155/2018/5379085
Marina Shevchenko5
Estimated H-index: 5
(RAS: Russian Academy of Sciences),
Andrey O. Bogorodskiy4
Estimated H-index: 4
(MIPT: Moscow Institute of Physics and Technology)
+ 8 AuthorsAlexander M. Sapozhnikov10
Estimated H-index: 10
(RAS: Russian Academy of Sciences)
Susceptibility to fungal infection is commonly associated with impaired neutrophil responses. To study the mechanisms underlying this association, we investigated neutrophil recruitment to the conducting airway wall after Aspergillus fumigatus conidium inhalation in mouse models of drug-induced immunosuppression and antibody-mediated neutrophil depletion (neutropenia) by performing three-dimensional confocal laser-scanning microscopy of whole-mount primary bronchus specimens. Actin staining enabled visualization of the epithelial and smooth muscle layers that mark the airway wall. Gr-1
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