Hsp90 chaperones hemoglobin maturation in erythroid and nonerythroid cells
Volume: 115, Issue: 6
Published: Jan 22, 2018
Abstract
Maturation of adult (α2β2) and fetal hemoglobin (α2γ2) tetramers requires that heme be incorporated into each globin. While hemoglobin alpha (Hb-α) relies on a specific erythroid chaperone (alpha Hb-stabilizing protein, AHSP), the other chaperones that may help mature the partner globins (Hb-γ or Hb-β) in erythroid cells, or may enable nonerythroid cells to express mature Hb, are unknown. We investigated a role for heat-shock protein 90 (hsp90)...
Paper Details
Title
Hsp90 chaperones hemoglobin maturation in erythroid and nonerythroid cells
Published Date
Jan 22, 2018
Volume
115
Issue
6
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