Runs of homozygosity: windows into population history and trait architecture
Abstract
Runs of homozygosity (ROH) are genomic regions of homozygosity where the identical maternal and paternal haplotypes are descended from a shared common ancestor, and they are well known to occur as a result of inbreeding. This article discusses strategies for detecting ROH, their underappreciated prevalence across diverse outbred populations and implications for complex traits and human disease. Long runs of homozygosity (ROH) arise when...
Paper Details
Title
Runs of homozygosity: windows into population history and trait architecture
Published Date
Jan 15, 2018
Journal
Volume
19
Issue
4
Pages
220 - 234
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Notes
History