Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men

Serum estradiol (E2) and estrone (E1) levels exhibit substantial heritability. To investigate the genetic regulation of serum E2 and E1 in men. Genome-wide association study in 11,097 men of European origin from nine epidemiological cohorts. Genetic determinants of serum E2 and E1 levels. Variants in/near CYP19A1 demonstrated the strongest evidence for association with E2, resolving to three independent signals. Two additional independent...