Discovery of Novel Muscarinic Receptor Modulators by Integrating a Natural Product Framework and a Bioactive Molecule

Muscarinic acetylcholine receptors (mAChRs) are important therapeutic targets for several diseases of the central nervous system and periphery. However, the lack of subtype‐selective ligands for these receptors is a major challenge. A novel approach involving the integration of a natural product framework with a bioactive molecule ( i NPBM) by using gephyrotoxin and the isoindoline framework is demonstrated for the discovery of new and selective...