Ether‐à‐go‐go K⁺ channels: effective modulators of neuronal excitability

Mammalian ether‐à‐go‐go (EAG) channels are voltage‐gated K + channels. They are encoded by the KCNH gene family and divided into three subfamilies, eag (Kv10), erg (eag‐related gene; Kv11) and elk (eag‐like; Kv12). All EAG channel subtypes are expressed in the brain where they effectively modulate neuronal excitability. This Topical Review describes the biophysical properties of each of the EAG channel subtypes, their function in neurons and the...