An image‐based small‐molecule screen identifies vimentin as a pharmacologically relevant target of simvastatin in cancer cells

Volume: 32, Issue: 5, Pages: 2841 - 2854
Published: Jan 18, 2018
Abstract
Vimentin is a cytoskeletal intermediate filament protein that is expressed in mesenchymal cells and cancer cells during the epithelial-mesenchymal transition. The goal of this study was to identify vimentin-targeting small molecules by using the Tocriscreen library of 1120 biochemically active compounds. We monitored vimentin filament reorganization and bundling in adrenal carcinoma SW13 vimentin-positive (SW13-vim+) cells via indirect...
Paper Details
Title
An image‐based small‐molecule screen identifies vimentin as a pharmacologically relevant target of simvastatin in cancer cells
Published Date
Jan 18, 2018
Volume
32
Issue
5
Pages
2841 - 2854
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