Garcinia xanthochymus extract protects PC12 cells from H 2 O 2 -induced apoptosis through modulation of PI3K/AKT and NRF2/HO-1 pathways

The aim of the present study was to investigate the protective effects and underlying mechanisms of Garcinia xanthochymus, a perennial medicinal plant native to Yunnan, China, against H2O2-induced oxidative damage in rat pheochromacytoma PC12 cells. Preincubation of PC12 cells with fruit EtOAc fraction (fruit-EFr., 12.5–50 µmol·L−1) of G. xanthochymus for 24 h prior to H2O2 exposure markedly improved cell viability and increased the activities...