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A comparative survey between non-systemic Salmonella spp. (paratyphoid group) and systemic Salmonella Pullorum and S. Gallinarum with a focus on virulence genes

Published on Oct 1, 2017in Pesquisa Veterinaria Brasileira 0.30
· DOI :10.1590/s0100-736x2017001000004
Claudete S. Astolfi-Ferreira7
Estimated H-index: 7
(USP: University of São Paulo),
Marcelo R.S. Pequini1
Estimated H-index: 1
(USP: University of São Paulo)
+ 5 AuthorsAntonio José Piantino Ferreira16
Estimated H-index: 16
(USP: University of São Paulo)
  • References (26)
  • Citations (1)
Published on Apr 1, 2008in Cell Host & Microbe 15.75
Rheinallt M. Jones20
Estimated H-index: 20
(Emory University),
Huixia Wu13
Estimated H-index: 13
(Emory University)
+ 3 AuthorsAndrew S. Neish48
Estimated H-index: 48
(Emory University)
Summary Salmonellae are bacterial pathogens that have evolved sophisticated strategies to evade host immune defenses. These strategies include the secretion of effector proteins into mammalian cells so as to subvert innate immune and apoptotic signaling pathways, thereby allowing Salmonella to avoid elimination. Here, we show that the secreted Salmonella typhimurium effector protein AvrA possesses acetyltransferase activity toward specific mitogen-activated protein kinase kinases (MAPKKs) and po...
Published on Oct 1, 2002in International Journal of Food Microbiology 4.01
Kuang Sheng Yeh17
Estimated H-index: 17
T.-H Chen1
Estimated H-index: 1
+ 2 AuthorsH.-C Lo1
Estimated H-index: 1
Abstract This study evaluated the suitability of fimY gene amplification by PCR as an effective means of detecting Salmonella species. Although fimY gene of Salmonella typhimurium is involved in regulating type 1 fimbrial expression, the amino acid sequence of FimY shares very little homology with other known prokaryotic proteins in the GenBank database. Therefore, fimY is a promising target gene to detect the presence of Salmonella species. Herein, two primers internal to the fimY gene of S. ty...
Published on Sep 15, 2002in Journal of Immunology 4.72
Lauren S. Collier-Hyams8
Estimated H-index: 8
(Emory University),
Hui Zeng6
Estimated H-index: 6
(Emory University)
+ 6 AuthorsAndrew S. Neish48
Estimated H-index: 48
(Emory University)
Secreted prokaryotic effector proteins have evolved to modulate the cellular functions of specific eukaryotic hosts. Generally, these proteins are considered virulence factors that facilitate parasitism. However, in certain plant and insect eukaryotic/prokaryotic relationships, effector proteins are involved in the establishment of commensal or symbiotic interactions. In this study, we report that the AvrA protein from Salmonella typhimurium , a common enteropathogen of humans, is an effector mo...
Published on Jul 1, 2002in Infection and Immunity 3.16
Shuping Zhang11
Estimated H-index: 11
(A&M: Texas A&M University),
Renato L. Santos37
Estimated H-index: 37
(A&M: Texas A&M University)
+ 4 AuthorsL. Garry Adams39
Estimated H-index: 39
(A&M: Texas A&M University)
Salmonella enterica serotype Typhimurium requires a functional type III secretion system encoded by Salmonella pathogenicity island 1 (SPI1) to cause diarrhea. We investigated the role of genes encoding secreted target proteins of the SPI1-associated type III secretion system for enteropathogenicity in calves. Salmonella serotype Typhimurium strains having mutations in sptP, avrA, sspH1, or slrP induced fluid secretion in the bovine ligated ileal loop model at levels similar to that of the wild ...
Published on Jan 1, 2002in Microbes and Infection 2.67
Tyler G. Kimbrough8
Estimated H-index: 8
(UW: University of Washington),
Samuel I. Miller76
Estimated H-index: 76
(UW: University of Washington)
The type III secretion needle complex (NC) of Salmonella typhimurium is a complex secretory system that functions to translocate virulence proteins into eukaryotic cells. Evolutionarily it is related to bacterial flagella. Assembly of the NC occurs through ordered secretion, polymerization, and assembly, and requires the coordinated expression and association of over 20 different proteins. Recent progress in the understanding of the assembly and architecture of the NC is reviewed.
Published on Nov 1, 2001in Microbes and Infection 2.67
Denise M. Monack59
Estimated H-index: 59
(Stanford University),
William Wiley Navarre22
Estimated H-index: 22
(NYU: New York University),
Stanley Falkow108
Estimated H-index: 108
(Stanford University)
Salmonella typhimurium invades host macrophages and can induce either an almost immediate cell death or establish an intracellular niche within the phagocytic vacuole. Rapid cell death depends on the Salmonella pathogenicity island SPI1 and the host protein caspase-1, a member of the pro-apoptotic caspase family of proteases. Caspase-1-dependent cell death leads to the activation of the potent pro-inflammatory cytokines interleukin (IL)-1β and IL-18 to produce bioactive cytokines. Animal studies...
Published on Aug 1, 2001in Journal of Bacteriology 3.23
Hidenori Matsui6
Estimated H-index: 6
(UF: University of Florida),
Christopher M. Bacot1
Estimated H-index: 1
(UF: University of Florida)
+ 3 AuthorsPaul A. Gulig24
Estimated H-index: 24
(UF: University of Florida)
In a mouse model of systemic infection, the spv genes carried on the Salmonella enterica serovar Typhimurium virulence plasmid increase the replication rate of salmonellae in host cells of the reticuloendothelial system, most likely within macrophages. A nonpolar deletion in the spvB gene greatly decreased virulence but could not be complemented by spvB alone. However, a low-copy-number plasmid expressing spvBC from a constitutive lacUV5 promoter did complement the spvB deletion. By examining a ...
Published on Apr 1, 2001in Journal of Bacteriology 3.23
Susanne Mirold10
Estimated H-index: 10
Kristin Ehrbar8
Estimated H-index: 8
+ 4 AuthorsWolf-Dietrich Hardt53
Estimated H-index: 53
Salmonella spp. possess a conserved type III secretion system encoded within the pathogenicity island 1 (SPI1; centisome 63), which mediates translocation of effector proteins into the host cell cytosol to trigger responses such as bacterial internalization. Several translocated effector proteins are encoded in other regions of the Salmonella chromosome. It remains unclear how this complex chromosomal arrangement of genes for the type III apparatus and the effector proteins emerged and how the d...
Published on Dec 1, 2000in International Journal of Medical Microbiology 3.36
Rita Prager41
Estimated H-index: 41
(RKI: Robert Koch Institute),
Susanne Mirold10
Estimated H-index: 10
(LMU: Ludwig Maximilian University of Munich)
+ 5 AuthorsHelmut Tschäpe44
Estimated H-index: 44
(RKI: Robert Koch Institute)
Abstract Pathogenic Salmonella enterica strains are capable of causing local and/or systemic infections. They employ two type III secretion systems to translocate an array of virulence-associated proteins (effector proteins) directly into the cytosol of target cells of the host. Earlier data had shown that changes in the repertoire of translocated effector proteins may contribute to the adaptation of Salmonella strains to new hosts and to the emergence of epidemic strains. Using PCR and Southern...
Robert Edwards93
Estimated H-index: 93
Dieter M. Schifferli25
Estimated H-index: 25
Stanley Maloy26
Estimated H-index: 26
Enteric bacteria possess multiple fimbriae, many of which play critical roles in attachment to epithelial cell surfaces. SEF14 fimbriae are only found in Salmonella enterica serovar Enteritidis (S. enteritidis) and closely related serovars, suggesting that SEF14 fimbriae may affect serovar-specific virulence traits. Despite evidence that SEF14 fimbriae are expressed by S. enteritidis in vivo, previous studies showed that SEF14 fimbriae do not mediate adhesion to the intestinal epithelium. Theref...
Cited By1
Published on May 22, 2019in Equine Veterinary Journal 2.12
C.P. Bustos2
Estimated H-index: 2
(UBA: University of Buenos Aires),
M. Moroni + 5 AuthorsP. Chacana (INTA: International Trademark Association)