Repeated Domperidone treatment modulates pulmonary cytokines in LPS-induced acute lung injury in mice
Abstract
The dopaminergic antagonist drug Domperidone has immunomodulatory effects. We investigated the effects of repeated Domperidone treatment in a model of Lypopolyssacharide (LPS)-induced acute lung inflammation. Adult C57BL/6J mice were treated with either Vehicle or Domperidone for 5 days, and challenged intranasally with LPS in the following day. The behavior of mice was analyzed in the open field and elevated plus-maze test before and 24 h after...
Paper Details
Title
Repeated Domperidone treatment modulates pulmonary cytokines in LPS-induced acute lung injury in mice
Published Date
Mar 1, 2018
Volume
56
Pages
43 - 50
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