Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons
Abstract
Arc/Arg3.1 is required for synaptic plasticity and cognition, and mutations in this gene are linked to autism and schizophrenia. Arc bears a domain resembling retroviral/retrotransposon Gag-like proteins, which multimerize into a capsid that packages viral RNA. The significance of such a domain in a plasticity molecule is uncertain. Here, we report that the Drosophila Arc1 protein forms capsid-like structures that bind darc1 mRNA in neurons and...
Paper Details
Title
Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons
Published Date
Jan 1, 2018
Journal
Volume
172
Issue
1-2
Pages
262 - 274.e11
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