Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming
Abstract
Long-term epigenetic reprogramming of innate immune cells in response to microbes, also termed "trained immunity," causes prolonged altered cellular functionality to protect from secondary infections. Here, we investigated whether sterile triggers of inflammation induce trained immunity and thereby influence innate immune responses. Western diet (WD) feeding of Ldlr-/- mice induced systemic inflammation, which was undetectable in serum soon...
Paper Details
Title
Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming
Published Date
Jan 1, 2018
Journal
Volume
172
Issue
1-2
Pages
162 - 175.e14
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Notes
History