Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes.

Volume: 127, Issue: 2, Pages: 187 - 214
Published: Jan 11, 2018
Abstract
DNA double-strand breaks arise accidentally upon exposure of DNA to radiation and chemicals or result from faulty DNA metabolic processes. DNA breaks can also be introduced in a programmed manner, such as during the maturation of the immune system, meiosis, or cancer chemo- or radiotherapy. Cells have developed a variety of repair pathways, which are fine-tuned to the specific needs of a cell. Accordingly, vegetative cells employ mechanisms that...
Paper Details
Title
Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes.
Published Date
Jan 11, 2018
Journal
Volume
127
Issue
2
Pages
187 - 214
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