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The family Coriobacteriaceae is a potential contributor to the beneficial effects of Roux-en-Y gastric bypass on type 2 diabetes

Published on Jan 1, 2018in Surgery for Obesity and Related Diseases3.758
· DOI :10.1016/j.soard.2018.01.012
Haijun Liu4
Estimated H-index: 4
(Southern Medical University),
Hong Zhang1
Estimated H-index: 1
(SJTU: Shanghai Jiao Tong University)
+ 3 AuthorsXueli Zhang4
Estimated H-index: 4
(Southern Medical University)
Sources
Abstract
Abstract Background Changes in gut microbiota induced by bariatric surgery have been associated with metabolic benefits. Objectives Our aim was to identify specific gut microbiota that may contribute to the improvement of type 2 diabetes (T2D) after Roux-en-Y gastric bypass (RYGB). Setting Laboratories of Shanghai Diabetes Institute and Shanghai Sixth People's Hospital. Methods Diabetic rats induced via a high-fat diet and low-dose streptozotocin administration were randomized to RYGB or sham surgery, and stool samples were collected at baseline and at postoperative week 8. The fecal microbiota was profiled using 16S ribosomal RNA gene sequencing. Additionally, we performed a case-control study of the gut microbial community profiles of T2D patients compared with those of healthy individuals via 16S ribosomal RNA gene sequencing of mucosal-luminal interface samples collected from the ascending colon during colonoscopy. Results RYGB significantly reduced the weight and improved glucose tolerance and insulin sensitivity in diabetic rats. Principal coordinate analysis showed that RYGB caused marked alterations in the gut microbiota. The RYGB group was postoperatively enriched for Bacteroidetes , Proteobacteria , Fusobacteria , and Actinobacteria , whereas the sham surgery group was enriched for Firmicutes and Verrucomicrobia . Based on the gut microbial patterns in the T2D patients, we found that the family Coriobacteriaceae within Actinobacteria might contribute to the beneficial effects of RYGB on T2D. Conclusions RYGB significantly improves glucose metabolism and alters the gut microbiota. Moreover, the family Coriobacteriaceae may partly mediate the beneficial effects of RYGB on T2D and thus possibly contribute to the development of novel bacteria-based therapeutic approaches.
  • References (31)
  • Citations (7)
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References31
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#1Haijun LiuH-Index: 4
#2Cheng Hu (SJTU: Shanghai Jiao Tong University)H-Index: 28
Last. Weiping Jia (SJTU: Shanghai Jiao Tong University)H-Index: 55
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Type 2 diabetes mellitus is becoming increasingly prevalent worldwide and has become one of the greatest threats to global health. Bariatric surgery was initially designed to achieve weight loss and subsequently was noted to induce improvements or remission of type 2 diabetes. Currently, these bariatric operations such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are the most effective procedures for the treatment of obesity and type 2 diabetes mellitus worldwide. However, the ...
26 CitationsSource
#1Cyrus Jahansouz (UMN: University of Minnesota)H-Index: 6
#2Christopher Staley (UMN: University of Minnesota)H-Index: 22
Last. Sayeed Ikramuddin (UMN: University of Minnesota)H-Index: 42
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Abstract Background Changes in the gut microbiome following bariatric surgery have been causally linked to metabolic benefits. Objectives We sought to characterize and assess the stability of gut microbiome shifts following sleeve gastrectomy (SG). Setting University laboratories. Methods Diet-induced obese mice were randomized to SG or sham surgery. Mice were housed individually or cohoused such that one SG mouse was housed with one weight-matched, sham-operated mouse. Fecal samples were collec...
8 CitationsSource
#1Rinki Murphy (University of Auckland)H-Index: 22
#2Peter Tsai (University of Auckland)H-Index: 15
Last. Michael Booth (North Shore Hospital)H-Index: 8
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Background It is unclear whether specific gut microbiota is associated with remission of type 2 diabetes (T2D) after distinct types of bariatric surgery.
53 CitationsSource
#1Yan Guo ('SMMU': Second Military Medical University)H-Index: 1
#2Chao-Qian Liu ('SMMU': Second Military Medical University)H-Index: 1
Last. Dajin Zou ('SMMU': Second Military Medical University)H-Index: 12
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Recent work with gut microbiota after bariatric surgery is limited, and the results have not been in agreement. Given the role of the gut microbiota in regulating host metabolism, we explored the effect of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) on the modifications of gut microbiota with regard to the potential influence of food intake and/or weight loss and examined their links with host metabolism. Zucker diabetic fatty rats were divided into the following groups: RYGB; sh...
22 CitationsSource
#1Philip R. SchauerH-Index: 61
#2Deepak L. Bhatt (Harvard University)H-Index: 122
Last. Sangeeta R. KashyapH-Index: 23
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BackgroundLong-term results from randomized, controlled trials that compare medical therapy with surgical therapy in patients with type 2 diabetes are limited. MethodsWe assessed outcomes 5 years after 150 patients who had type 2 diabetes and a body-mass index (BMI; the weight in kilograms divided by the square of the height in meters) of 27 to 43 were randomly assigned to receive intensive medical therapy alone or intensive medical therapy plus Roux-en-Y gastric bypass or sleeve gastrectomy. Th...
519 CitationsSource
#1Yikai Shao (Fudan University)H-Index: 3
#2Rui Ding (Fudan University)H-Index: 3
Last. Qiyuan Yao (Fudan University)H-Index: 3
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Background The objective of the study was to compare gut microbiota post Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG).
26 CitationsSource
The large majority of studies on the role of the microbiome in the pathogenesis of disease are correlative and preclinical; several have influenced clinical practice.
433 CitationsSource
#1Walid Mottawea (U of O: University of Ottawa)H-Index: 8
#2Cheng-Kang Chiang (U of O: University of Ottawa)H-Index: 9
Last. Alain Stintzi (U of O: University of Ottawa)H-Index: 32
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Intestinal microbial dysbiosis is associated with Crohn’s disease (CD). However, the mechanisms leading to the chronic mucosal inflammation that characterizes this disease remain unclear. In this report, we use systems-level approaches to study the interactions between the gut microbiota and host in new-onset paediatric patients to evaluate causality and mechanisms of disease. We report an altered host proteome in CD patients indicative of impaired mitochondrial functions. In particular, mitocho...
72 CitationsSource
#1James H. MehaffeyH-Index: 12
#2Damien J. LaParH-Index: 31
Last. Bruce D. SchirmerH-Index: 35
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The aim of the study was to evaluate the clinical effectiveness and long-term durability of Roux-en-Y Gastric Bypass (RYGB) at an accredited center.Short-term data have established the effectiveness of RYGB for weight loss and comorbidity amelioration. The long-term durability of this operation remains infrequently described in the American population.All patients (N = 1087) undergoing RYGB at a single institution over a 20-year study period (1985-2004) were evaluated. Univariate differences in ...
71 CitationsSource
#1Yong Yan (Southern Medical University)H-Index: 2
#2Zhou Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 2
Last. Xueli Zhang (Southern Medical University)H-Index: 4
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Background Roux-en-Y gastric bypass (RYGB) is an effective surgical treatment for type 2 diabetes mellitus (T2DM). The present study aimed to investigate the effects of RYGB on glucose homeostasis, lipid metabolism, and intestinal morphological adaption, as well as hepatic and intestinal gluconeogenesis.
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Substantial differences in the response of gut microbial composition to metabolic and bariatric surgery have been reported. Therefore, the goal of the present review is to evaluate if methodological differences could be driving this lack of consistency. A search was conducted using PUBMED, Web of Science, Science Direct and COCHRANE using the following inclusion criteria: human studies written in English with a baseline sampling point, using gut microbiota as an outcome and either Roux-n-Y gastr...
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