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Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses

Published on Apr 1, 2018in Diabetologia7.11
· DOI :10.1007/s00125-017-4526-6
Lily Boutens7
Estimated H-index: 7
(WUR: Wageningen University and Research Centre),
Guido Hooiveld37
Estimated H-index: 37
(WUR: Wageningen University and Research Centre)
+ 3 AuthorsRinke Stienstra29
Estimated H-index: 29
(WUR: Wageningen University and Research Centre)
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Abstract
Aims/hypothesis Recent studies have identified intracellular metabolism as a fundamental determinant of macrophage function. In obesity, proinflammatory macrophages accumulate in adipose tissue and trigger chronic low-grade inflammation, that promotes the development of systemic insulin resistance, yet changes in their intracellular energy metabolism are currently unknown. We therefore set out to study metabolic signatures of adipose tissue macrophages (ATMs) in lean and obese conditions.
  • References (42)
  • Citations (21)
Cite
References42
Newest
Published on Mar 1, 2017in Nature microbiology14.30
Ekta Lachmandas10
Estimated H-index: 10
,
Lily Boutens7
Estimated H-index: 7
+ 9 AuthorsR. van Crevel44
Estimated H-index: 44
While stimulation of TLR4 with LPS leads to an increase in glycolysis and a decrease in oxidative phosphorylation, complex microbial stimuli and the TLR2 ligand P3C induce upregulation of both glycolysis and oxidative phosphorylation.
Published on Jan 31, 2017in Frontiers in Immunology4.72
P. Kent Langston1
Estimated H-index: 1
(Harvard University),
Munehiko Shibata4
Estimated H-index: 4
(Harvard University),
Tiffany Horng21
Estimated H-index: 21
(Harvard University)
Macrophages are found in most tissues of the body, where they have tissue- and context-dependent roles in maintaining homeostasis as well as coordinating adaptive responses to a variety of stresses. Their capacity for specialized functions is controlled by polarizing signals, which activate (or polarize) macrophages by upregulating transcriptional programs that encode distinct effector functions. An important conceptual advance in the field of macrophage biology, emerging from recent studies, is...
Published on Dec 1, 2016in Diabetes7.20
Akiko Takikawa5
Estimated H-index: 5
(University of Toyama),
Arshad Mahmood15
Estimated H-index: 15
(University of Toyama)
+ 21 AuthorsMasashi Ikutani13
Estimated H-index: 13
(University of Toyama)
Adipose tissue hypoxia is an important feature of pathological adipose tissue expansion. Hypoxia-inducible factor-1α (HIF-1α) in adipocytes reportedly induces oxidative stress and fibrosis, rather than neoangiogenesis via VEGF-A. We previously reported that macrophages in crown-like structures (CLSs) are both hypoxic and inflammatory. In the present study, we examined how macrophage HIF-1α is involved in high-fat diet (HFD)-induced inflammation, neovascularization, hypoxia, and insulin resistanc...
Published on Oct 3, 2016in Journal of Clinical Investigation12.28
Sarah E. Corcoran6
Estimated H-index: 6
,
Luke A.J. O’Neill34
Estimated H-index: 34
Abstract HIF1α is a common component of pathways involved in the control of cellular metabolism and has a role in regulating immune cell effector functions. Additionally, HIF1α is critical for the maturation of dendritic cells and for the activation of T cells. HIF1α is induced in LPS-activated macrophages, where it is critically involved in glycolysis and the induction of proinflammatory genes, notably Il1b. The mechanism of LPS-stimulated HIF1α induction involves succinate, which inhibits prol...
Published on Jun 1, 2016in Journal of Lipid Research4.74
Abigail S. Haka19
Estimated H-index: 19
(Cornell University),
Valéria C. Barbosa-Lorenzi5
Estimated H-index: 5
(Cornell University)
+ 4 AuthorsFrederick R. Maxfield84
Estimated H-index: 84
(Cornell University)
Many types of apoptotic cells are phagocytosed and digested by macrophages. Adipocytes can be hundreds of times larger than macrophages, so they are too large to be digested by conventional phagocytic processes. The nature of the interaction between macrophages and apoptotic adipocytes has not been studied in detail. We describe a cellular process, termed exophagy, that is important for macrophage clearance of dead adipocytes and adipose tissue homeostasis. Using mouse models of obesity, human t...
Published on May 1, 2016in Diabetologia7.11
Lily Boutens7
Estimated H-index: 7
(Radboud University Nijmegen),
Rinke Stienstra29
Estimated H-index: 29
(Radboud University Nijmegen)
Inflammation originating from the adipose tissue is considered to be one of the main driving forces for the development of insulin resistance and type 2 diabetes in obese individuals. Although a plethora of different immune cells shapes adipose tissue inflammation, this review is specifically focused on the contribution of macrophages that reside in adipose tissue in lean and obese conditions. Both conventional and tissue-specific functions of adipose tissue macrophages (ATMs) in lean and obese ...
Published on Sep 1, 2015in Cell Metabolism22.41
Francesc Baixauli10
Estimated H-index: 10
(ISCIII: Instituto de Salud Carlos III),
Rebeca Acín-Pérez30
Estimated H-index: 30
(ISCIII: Instituto de Salud Carlos III)
+ 10 AuthorsJuan M. Falcon-Perez25
Estimated H-index: 25
(Ikerbasque)
Summary The endolysosomal system is critical for the maintenance of cellular homeostasis. However, how endolysosomal compartment is regulated by mitochondrial function is largely unknown. We have generated a mouse model with defective mitochondrial function in CD4 + T lymphocytes by genetic deletion of the mitochondrial transcription factor A (Tfam). Mitochondrial respiration deficiency impairs lysosome function, promotes p62 and sphingomyelin accumulation, and disrupts endolysosomal trafficking...
Published on Mar 1, 2015in Immunity21.52
Abhishek K. Jha18
Estimated H-index: 18
(Agios Pharmaceuticals),
Stanley Ching-Cheng Huang20
Estimated H-index: 20
(WashU: Washington University in St. Louis)
+ 10 AuthorsBart Everts25
Estimated H-index: 25
(WashU: Washington University in St. Louis)
Summary Macrophage polarization involves a coordinated metabolic and transcriptional rewiring that is only partially understood. By using an integrated high-throughput transcriptional-metabolic profiling and analysis pipeline, we characterized systemic changes during murine macrophage M1 and M2 polarization. M2 polarization was found to activate glutamine catabolism and UDP-GlcNAc-associated modules. Correspondingly, glutamine deprivation or inhibition of N-glycosylation decreased M2 polarizatio...
Published on Mar 1, 2015in Endocrinology3.80
Theresa Schöttl5
Estimated H-index: 5
(TUM: Technische Universität München),
Lisa Kappler2
Estimated H-index: 2
(TUM: Technische Universität München)
+ 2 AuthorsMartin Klingenspor46
Estimated H-index: 46
(TUM: Technische Universität München)
Accumulation of visceral fat is associated with metabolic risk whereas excessive amounts of peripheral fat are considered less problematic. At the same time, altered white adipocyte mitochondrial bioenergetics has been implicated in the pathogenesis of insulin resistance and type 2 diabetes. We therefore investigated whether the metabolic risk of visceral vs peripheral fat coincides with a difference in mitochondrial capacity of white adipocytes. We assessed bioenergetic parameters of subcutaneo...
Published on Dec 1, 2014in Diabetes7.20
Rinke Stienstra29
Estimated H-index: 29
(Radboud University Nijmegen),
Wieneke Dijk9
Estimated H-index: 9
(WUR: Wageningen University and Research Centre)
+ 8 AuthorsCees J. Tack39
Estimated H-index: 39
(Radboud University Nijmegen)
Obesity is accompanied by the presence of chronic low-grade inflammation manifested by infiltration of macrophages into adipose tissue. Mannose-binding lectin (MBL), a soluble mediator of innate immunity, promotes phagocytosis and alters macrophage function. To assess the function of MBL in the development of obesity, we studied wild-type and MBL −/− mice rendered obese using a high-fat diet (HFD). Whereas no gross morphological differences were observed in liver, an HFD provoked distinct change...
Cited By21
Newest
Published on Mar 27, 2019in Current obesity reports
Heather L. Caslin (Vandy: Vanderbilt University), Alyssa H. Hasty46
Estimated H-index: 46
(Vandy: Vanderbilt University)
Purpose of Review Research over the past decade has shown that immunologic and metabolic pathways are intricately linked. This burgeoning field of immunometabolism includes intrinsic and extrinsic pathways and is known to be associated with obesity-accelerated metabolic disease. Intrinsic immunometabolism includes the study of fuel utilization and bioenergetic pathways that influence immune cell function. Extrinsic immunometabolism includes the study of immune cells and products that influence s...
Published on Jul 2, 2019in Clinical & Experimental Allergy4.74
Torsten Schröder7
Estimated H-index: 7
(University of Lübeck),
Anna V. Wiese4
Estimated H-index: 4
(University of Lübeck)
+ 13 AuthorsStefanie Derer16
Estimated H-index: 16
Published on Apr 27, 2019in Neurological Sciences2.48
Hua Pan1
Estimated H-index: 1
,
Xiuji Huang (SYSU: Sun Yat-sen University)+ 4 AuthorsMuchao Wu4
Estimated H-index: 4
(SYSU: Sun Yat-sen University)
The level of lactate in the blood is associated with obesity, blood pressure, and type 2 diabetes. In addition, lactate is a pro-inflammatory cytokine, which plays an important role in the pathogenesis of cognitive impairment. However, the association between blood lactate, systemic inflammation, and mild cognitive impairment (MCI) has not been investigated. The aim of the study is to explore this association in a Chinese population. This community-based cross-sectional study included 2523 Chine...
Published in Trends in Immunology13.00
Harry Kane (Trinity College, Dublin), Lydia Lynch23
Estimated H-index: 23
(Trinity College, Dublin)
Adipose tissue is a critical regulator of systemic metabolism and normal bodily homeostasis. Recently, the immune system has been implicated in the regulation of adipose tissue homeostasis and function. Here, we highlight new insights into the distinct phenotypes and functions of adipose resident leukocytes, including a growing body of work on their role in adipose tissue remodeling and thermogenesis. We discuss how the protective capacity of the adipose immune system can be diminished during ob...
Published on Jul 9, 2019
Joseph Roberts , Padraic G. Fallon59
Estimated H-index: 59
,
Emily Hams24
Estimated H-index: 24
Published on Jul 1, 2019in Obesity Research & Clinical Practice2.06
Bo Liu3
Estimated H-index: 3
(University of Adelaide),
Amy T. Hutchison7
Estimated H-index: 7
(University of Adelaide)
+ 2 AuthorsLeonie K. Heilbronn37
Estimated H-index: 37
(University of Adelaide)
Abstract Objective This study compared the effects of daily calorie restriction (DR) versus intermittent fasting (IF) on markers of inflammation and extracellular matrix deposition in adipose tissue and skeletal muscle in a controlled feeding trial in women with overweight or obesity. Methods Women (N = 76) were randomised to one of three diets and provided with all foods at 100% (IF100) or 70% (IF70 and DR70) of calculated energy requirements for 8 weeks. IF groups ate breakfast prior to fastin...
Published on Apr 5, 2019in Seminars in Immunopathology6.80
Elise Dalmas (Paris Diderot University)
Growing evidence suggests that components of the innate immune system play a crucial role in regulating metabolic homeostasis. Macrophages were the primary immune cells to be described in both the white adipose tissue and the pancreatic islets. Therein, their functions, beneficial or detrimental, are extending under steady state and in the context of obesity-induced type 2 diabetes. Other populations, including innate lymphoid cells, are emerging as key sentinels of metabolic tissues and privile...
Parvin Bolori (Tehran University of Medical Sciences), Leila Setaysh (Tehran University of Medical Sciences)+ -3 AuthorsKhadijeh Mirzaei11
Estimated H-index: 11
(Tehran University of Medical Sciences)
Abstract Objective Obesity and overweight which are consequence of some interaction factor such as genetics and behavioral habit. Obesity as a metabolic disorder and chronic inflammation is a trigger to countless disease. The main goal of this study is to investigate the interaction of herbal diet on the levels of liver enzymes, inflammatory factors and adipocytes profile. Materials and methods A total of 240 adult women range of 18–48 years were included in the current comparative cross-section...
Published on Jun 21, 2019in European Journal of Immunology4.70
Jorge Domínguez-Andrés5
Estimated H-index: 5
(Radboud University Nijmegen Medical Centre),
Anaísa V Ferreira (University of Porto)+ 4 AuthorsMihai G. Netea103
Estimated H-index: 103
(University of Bonn)