The potential of circulating cell-free RNA as a cancer biomarker: challenges and opportunities

Introduction: Cancer statistics show that recent improvements in cancer management are only mildly effective in the absence of reliable biomarkers for the detection, diagnosis and monitoring of malignant disease. Recently circulating nucleic acids have been suggested as potential biomarker candidates to fill this role.Areas covered: This review focuses on the different types of circulating RNA biomarkers under investigation, describing the...