MiR-29 silencing modulates the expression of target genes related to proliferation, apoptosis and methylation in Burkitt lymphoma cells

Volume: 144, Issue: 3, Pages: 483 - 497
Published: Jan 9, 2018
Abstract
Burkitt lymphoma (BL) is a B-cell lymphoma frequently diagnosed in children. It is characterized by MYC translocations, which lead to the constitutive expression of the MYC oncogene. MYC contributes to miR-29 repression through an E-box MYC binding site on the miR-29b-1/miR-29a promoter region. We evaluated the role of miR-29a/b/c and their predicted targets in BL pathogenesis. Mature sequences of miR-29a/b/c were transfected to the BL cell...
Paper Details
Title
MiR-29 silencing modulates the expression of target genes related to proliferation, apoptosis and methylation in Burkitt lymphoma cells
Published Date
Jan 9, 2018
Volume
144
Issue
3
Pages
483 - 497
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