GPVI signaling is compromised in newly formed platelets after acute thrombocytopenia in mice
Abstract
At sites of vascular injury, exposed subendothelial collagens trigger platelet activation and thrombus formation by interacting with the immunoreceptor tyrosine-based activation motif (ITAM)-coupled glycoprotein VI (GPVI) on the platelet surface. Platelets are derived from the cytoplasm of megakaryocytes (MKs), which extend large proplatelets into bone marrow (BM) sinusoids that are then released into the bloodstream, where final platelet sizing...
Paper Details
Title
GPVI signaling is compromised in newly formed platelets after acute thrombocytopenia in mice
Published Date
Mar 8, 2018
Journal
Volume
131
Issue
10
Pages
1106 - 1110
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