The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure
Abstract
Sphingolipids are essential components of cellular membranes and defects in their synthesis or degradation cause severe human diseases. The efficient degradation of sphingolipids in the lysosome requires lipid-binding saposin proteins and hydrolytic enzymes. The glycosphingolipid galactocerebroside is the primary lipid component of the myelin sheath and is degraded by the hydrolase β-galactocerebrosidase (GALC). This enzyme requires the saposin...
Paper Details
Title
The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure
Published Date
Jan 11, 2018
Journal
Volume
9
Issue
1
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