Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases
Abstract
The recently discovered histone post-translational modification crotonylation connects cellular metabolism to gene regulation. Its regulation and tissue-specific functions are poorly understood. We characterize histone crotonylation in intestinal epithelia and find that histone H3 crotonylation at lysine 18 is a surprisingly abundant modification in the small intestine crypt and colon, and is linked to gene regulation. We show that this...
Paper Details
Title
Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases
Published Date
Jan 9, 2018
Journal
Volume
9
Issue
1
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