Insights into the effect of minor groove interactions and metal cofactors on mutagenic replication by human DNA polymerase β
Abstract
DNA polymerases accommodate various base-pair conformations in the event of incorrect insertions. In particular, Watson–Crick-like dG:dTTP base pair has been observed at the insertion site of human DNA polymerase β (pol β). A potential factor contributing to the diverse conformations of base-pair mismatches is minor groove interactions. To gain insights into the effect of minor groove interactions on base-pair conformations, we generated an...
Paper Details
Title
Insights into the effect of minor groove interactions and metal cofactors on mutagenic replication by human DNA polymerase β
Published Date
Feb 9, 2018
Journal
Volume
475
Issue
3
Pages
571 - 585
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