RET mutation heterogeneity in primary advanced medullary thyroid cancers and their metastases

Medullary Thyroid Cancer (MTC) whose pathogenesis is strictly related to RET proto-oncogene alterations, has been shown to have a heterogenic RET mutation profile in subpopulations of MTC. The aim of our study was to investigate the RET somatic mutation profile in primary MTC and in the corresponding metastatic tissues in a series of advanced metastatic cases.This study demonstrated that in about 20% of cases a different RET mutation profile can...