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Plasma fibrin clot structure and thromboembolism: clinical implications.

Published on Dec 11, 2017in Polish archives of internal medicine
· DOI :10.20452/pamw.4165
Michał Ząbczyk9
Estimated H-index: 9
,
Anetta Undas41
Estimated H-index: 41
Abstract
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  • Citations (24)
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Cited By24
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#1Krzysztof Bartus (Jagiellonian University Medical College)H-Index: 17
#1Krzysztof Bartus (Jagiellonian University Medical College)H-Index: 1
Last. Randall J. Lee (UCSF: University of California, San Francisco)H-Index: 54
view all 8 authors...
Abstract Introduction Atrial fibrillation (AF), a risk factor for strokes and systemic thromboembolisms, is associated with unfavorable fibrin clot properties and increased thrombus formation in peripheral blood. The left atrial appendage (LAA) is known to be the primary site of thrombus formation. Aim We investigated the relative differences in plasma fibrin clot features including plasma fibrin clot permeability (Ks) and clot lysis time (CLT) between the right atrium (RA), right ventricle (RV)...
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#1Emily Mihalko (UNC: University of North Carolina at Chapel Hill)H-Index: 3
#2Ashley C. Brown (UNC: University of North Carolina at Chapel Hill)H-Index: 14
The formation of a fibrin clot matrix plays a critical role in promoting hemostasis and wound healing. Fibrin dynamics can become disadvantageous in the formation of aberrant thrombus development. Structural characteristics of clots, such as fiber diameter, clot density, stiffness, or permeability, can determine overall clot integrity and functional characteristics that have implications on coagulation and fibrinolysis. This review examines known factors that contribute to changes in clot struct...
1 CitationsSource
#2Jana ŠtikarováH-Index: 5
Last. Jan E. DyrH-Index: 16
view all 8 authors...
Oxidative stress in humans is related to various pathophysiological processes, which can manifest in numerous diseases including cancer, cardiovascular diseases, and Alzheimer's disease. On the atomistic level, oxidative stress causes posttranslational modifications, thus inducing structural and functional changes into the proteins structure. This study focuses on fibrinogen, a blood plasma protein that is frequently targeted by reagents causing posttranslational modifications in proteins. Fibri...
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#1Konstanty Szułdrzyński (Jagiellonian University Medical College)H-Index: 2
#2Milosz Jankowski (Jagiellonian University Medical College)H-Index: 10
Last. Anetta Undas (Jagiellonian University Medical College)H-Index: 41
view all 4 authors...
Aims. Fibrin formation and histidine-rich glycoprotein (HRG) are involved in primary hemostasis and wound healing. Little is known regarding the relationship of clot characteristics, bleeding time, and wound healing. Methods and Results. We studied 154 patients with coronary artery disease (CAD) and 154 subjects free of CAD matched for age, obesity, and current smoking. We evaluated bleeding time (BT) using standardized skin incisions on a forearm, along with plasma clot permeability ( s), clot ...
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#2Tomasz Nowakowski (Jagiellonian University Medical College)
Last. Anetta UndasH-Index: 41
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Abstract Introduction Fibrin clot structure differs between healthy individuals and those following thromboembolic events. Dense and poorly lysable fibrin clots have also been reported in peripheral artery disease. We studied fibrin clot properties and its determinants in individuals with a history of acute lower limb ischemia (ALI) of unknown cause. Materials and methods In this case-control study, we enrolled 43 patients who experienced ALI of unknown cause, and two age-and sex-matched referen...
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#1Pavel PoredošH-Index: 12
#2Peter PoredošH-Index: 1
Last. Mateja Kaja Jezovnik (University of Texas at Austin)
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Summary. The outcome of a thrombotic vessel occlusion is related to the resolution of thrombus and restitution of blood flow. Thrombus formation simultaneously activates an enzymatic process that m...
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Abstract Background The post-translational protein modification via lysine residues can significantly alter its function. α2-antiplasmin, a key inhibitor of fibrinolysis, contains 19 lysine residues. Aim We sought to identify sites of glycation and acetylation in human α2-antiplasmin and test whether the competition might occur on the lysine residues of α2-antiplasmin. Methods We analyzed human α2-antiplasmin (1) untreated; (2) incubated with increasing concentrations of β- d -glucose (0, 5, 10,...
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#1Paweł Rubiś (Jagiellonian University)H-Index: 5
#2Joanna Natorska (Jagiellonian University Medical College)H-Index: 9
Last. Anetta Undas (Jagiellonian University Medical College)H-Index: 41
view all 9 authors...
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#1Agata Hanna Bryk (Jagiellonian University Medical College)H-Index: 3
#2Jakub Siudut (Jagiellonian University Medical College)H-Index: 5
Last. Anetta Undas (Jagiellonian University Medical College)H-Index: 41
view all 7 authors...
Abstract Background Type 2 diabetes mellitus (T2DM) is associated with hypofibrinolysis and increased factor XIII-mediated α2-antiplasmin incorporation into the fibrin clot. It is unclear whether there are sex-related differences in α2-antiplasmin incorporation in relation to impaired clot lysis in T2DM. Aim We investigated α2-antiplasmin incorporation into fibrin clots as a determinant of clot lysability in patients of both sexes with T2DM. Methods In a group of 113 T2DM patients, 54 (47.8%) of...
1 CitationsSource
#1Anetta Undas (Jagiellonian University)H-Index: 41
Compelling evidence indicates that a hypercoagulable state occurs in patients with atrial fibrillation (AF) including those in sinus rhythm following paroxysmal and persistent AF. Activation of blood coagulation in AF reflects heightened thrombin generation with the subsequent increased formation of fibrin as evidenced by elevated soluble fibrin monomers and D-dimer. Formation of denser fibrin meshworks, relatively resistant to plasmin-mediated lysis has been demonstrated in patients with AF. Th...
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