Human cytomegalovirus-encoded US9 targets MAVS and STING signaling to evade type I interferon immune responses
Abstract
Human cytomegalovirus (HCMV) has evolved sophisticated immune evasion mechanisms that target both the innate and adaptive immune responses. However, how HCMV encoded proteins are involved in this immune escape is not clear. Here, we show that HCMV glycoprotein US9 inhibits the IFN-β response by targeting the mitochondrial antiviral-signaling protein (MAVS) and stimulator of interferon genes (STING)-mediated signaling pathways. US9 accumulation...
Paper Details
Title
Human cytomegalovirus-encoded US9 targets MAVS and STING signaling to evade type I interferon immune responses
Published Date
Jan 9, 2018
Journal
Volume
9
Issue
1
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