Genetic variants demonstrating flip-flop phenomenon and breast cancer risk prediction among women of African ancestry

Few studies have evaluated the performance of existing breast cancer risk prediction models among women of African ancestry. In replication studies of genetic variants, a change in direction of the risk association is a common phenomenon. Termed flip-flop, it means that a variant is risk factor in one population but protective in another, affecting the performance of risk prediction models.We used data from the genome-wide association study...