Estrogen-regulated transcription: Mammary gland and uterus

Estrogen (E2) plays a central role in the developmental, metabolic and reproductive functions of both males and females. E2 acts via the estrogen receptor alpha (ERα) to regulate the transcription of genes involved in numerous cellular functions. The E2-dependent engagement of ERα across regulatory regions of the genome, termed "enhancers", exhibits a high degree of complexity and plasticity. The E2-transcriptional response is defined by pioneer...