Activity of apoptotic and inflammatory caspases in THP-1 cells treated with extracellular Hsp70

Introduction: Extracellular Hsp70 (eHsp70) was shown to be increased in serum of patients with lung diseases, such as chronic obstructive pulmonary disease (COPD). Some studies demonstrated that eHsp70 can act pro-inflammatory and trigger sterile inflammation via Toll like receptors (TLR) 2 and 4. Aims and objectives: We hypothesized that eHsp70 might induce inflammatory, but not necessarily cytotoxic effects in THP-1 cell line....