Structure and function of the N-terminal domain of the yeast telomerase reverse transcriptase

Volume: 46, Issue: 3, Pages: 1525 - 1540
Published: Dec 23, 2017
Abstract
The elongation of single-stranded DNA repeats at the 3′-ends of chromosomes by telomerase is a key process in maintaining genome integrity in eukaryotes. Abnormal activation of telomerase leads to uncontrolled cell division, whereas its down-regulation is attributed to ageing and several pathologies related to early cell death. Telomerase function is based on the dynamic interactions of its catalytic subunit (TERT) with nucleic acids—telomerase...
Paper Details
Title
Structure and function of the N-terminal domain of the yeast telomerase reverse transcriptase
Published Date
Dec 23, 2017
Volume
46
Issue
3
Pages
1525 - 1540
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