Systems biology analysis of mitogen activated protein kinase inhibitor resistance in malignant melanoma
Abstract
Kinase inhibition in the mitogen activated protein kinase (MAPK) pathway is a standard therapy for cancer patients with activating BRAF mutations. However, the anti-tumorigenic effect and clinical benefit are only transient, and tumors are prone to treatment resistance and relapse. To elucidate mechanistic insights into drug resistance, we have established an in vitro cellular model of MAPK inhibitor resistance in malignant melanoma. The...
Paper Details
Title
Systems biology analysis of mitogen activated protein kinase inhibitor resistance in malignant melanoma
Published Date
Apr 4, 2018
Journal
Volume
12
Issue
1
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