Genomic and Proteomic Resolution of Heterochromatin and Its Restriction of Alternate Fate Genes
Abstract
Heterochromatin is integral to cell identity maintenance by impeding the activation of genes for alternate cell fates. Heterochromatic regions are associated with histone 3 lysine 9 trimethylation (H3K9me3) or H3K27me3, but these modifications are also found in euchromatic regions that permit transcription. We discovered that resistance to sonication is a reliable indicator of the heterochromatin state, and we developed a biophysical method...
Paper Details
Title
Genomic and Proteomic Resolution of Heterochromatin and Its Restriction of Alternate Fate Genes
Published Date
Dec 1, 2017
Journal
Volume
68
Issue
6
Pages
1023 - 1037.e15
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