Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Abstract
Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding...
Paper Details
Title
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Published Date
Dec 22, 2017
Journal
Volume
50
Issue
1
Pages
26 - 41
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