Composite Biomarkers Derived from Micro-Electrode Array Measurements and Computer Simulations Improve the Classification of Drug-Induced Channel Block

The Micro-Electrode Array (MEA) device enables high-throughput electrophysiology measurements that are less labour-intensive than patch-clamp based techniques. Combined with human-induced pluripotent stem cells cardiomyocytes (hiPSC-CM), it represents a new and promising paradigm for automated and accurate \textit{in vitro} drug safety evaluation. In this article, the following question is addressed: which features of the MEA signals should be...