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Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652

Published on Jan 1, 2016
· DOI :10.1080/15548627.2015.1100356
Dj Klionsky1
Estimated H-index: 1
,
Kotb Abdelmohsen48
Estimated H-index: 48
+ 2382 AuthorsSm Zughaier1
Estimated H-index: 1
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#1Hugo Vicente Miranda (NOVA: Universidade Nova de Lisboa)H-Index: 14
#2Ana Chegão (NOVA: Universidade Nova de Lisboa)H-Index: 1
Last. Tiago F. Outeiro (GAU: University of Göttingen)H-Index: 47
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α-synuclein (aSyn) is a major player in Parkinson′s disease (PD) and a group of other disorders collectively known as synucleinopathies, but the precise molecular mechanisms involved are still unclear. aSyn, as virtually all proteins, undergoes a series of posttranslational modifications (PTMs) during its lifetime which can affect its biology and pathobiology. We recently showed that glycation of aSyn by methylglyoxal (MGO) potentiates its oligomerization and toxicity, induces dopaminergic neuro...
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#1Rishith Ravindran (Indian Institute of Science Education and Research, Thiruvananthapuram)H-Index: 1
#1Rishith Ravindran (Indian Institute of Science Education and Research, Thiruvananthapuram)H-Index: 1
Last. Srinivasa M Srinivasula (NCSE: National Center for Science Education)
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Mitochondrial quality control and homeostasis is ensured by removal of the damaged mitochondria involving lysosomal and proteasomal degradation mechanisms. Though much remains to be elucidated, recent findings suggest important roles for endosomal machinery in the elimination of damaged mitochondria. In this study, we report a novel function for a FYVE-like domain containing endosomal ubiquitin ligase, CARP2 in mitophagy. Our results show that endosomal CARP2 associates with damaged mitochondria...
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#1Schwertheim SH-Index: 7
#2S. TheurerH-Index: 1
Last. Kurt Werner SchmidH-Index: 58
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Background Intranuclear inclusions (NI) in normal and neoplastic tissues have been known for years, representing one of the diagnostic criteria for papillary thyroid carcinoma (PTC). BRAF activation is involved among others in autophagy. NI in hepatocellular carcinoma contain autophagy-associated proteins. Our aim was to clarify if NI in thyroid carcinoma (TC) have a biological function. Methods NI in 107 paraffin-embedded specimens of TC including all major subtypes were analyzed. We considered...
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#1Katarzyna Błaszczyk (Warsaw University of Life Sciences)H-Index: 4
#2Małgorzata Gajewska (Warsaw University of Life Sciences)H-Index: 16
Last. Joanna Gromadzka-Ostrowska (Warsaw University of Life Sciences)H-Index: 14
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Purpose Beta-glucans are biologically active polysaccharides having antioxidant, immunomodulatory, and antiinflammatory properties. This study investigated the transcriptomic profile in peripheral blood of rats with LPS-induced enteritis, which were fed a diet supplemented with high- (G1) and low- (G2) molecular-weight oat beta-glucans.
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#1Imke Tiessen (UCPH: University of Copenhagen)H-Index: 1
#2Marie H. Abildgaard (UCPH: University of Copenhagen)H-Index: 1
Last. Anders H. Lund (UCPH: University of Copenhagen)H-Index: 42
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Autophagy is a conserved degradation process that occurs in all eukaryotic cells and its dysfunction has been associated with various diseases including cancer. While a number of large-scale attempts have recently identified new molecular players in autophagy regulation, including proteins and microRNAs, little is known regarding the function of long non-coding RNAs (lncRNAs) in the regulation of this process. To identify new long non-coding RNAs with functional implications in autophagy, we per...
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#1Andrea Kapinová (Comenius University in Bratislava)H-Index: 7
#2Peter Kubatka (Comenius University in Bratislava)H-Index: 15
Last. Jan Danko (Comenius University in Bratislava)H-Index: 15
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Purpose Cancer is a serious health issue and a leading cause of death worldwide. Most of the cancer patients (approximately 90%) do not die from the consequences of the primary tumor development, but due to a heavily treatable metastatic invasion. During the lengthy multistep process of carcinogenesis, there are a lot of opportunities available to reverse or slow down the tissue invasion or the process of tumor metastasis formation.
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#1Chao-Yue Sun (Guangzhou University of Chinese Medicine)H-Index: 4
#2Qian-Yu Zhang (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Bing Feng (Guangzhou University of Chinese Medicine)H-Index: 4
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Autophagy is a ubiquitous catabolic process by which damaged or harmful intracellular components are delivered to the lysosomes for self-digestion and recycling. It is critical in cancer treatment. Therapy-induced autophagy predominantly acts as a pro-survival mechanism, but progressive autophagy can lead to non-apoptotic cell death, also known as autophagic cell death. Plants or herbs contain various natural compounds that are widely used in the treatment of many types of malignancies. Emerging...
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#1Roberto Coccurello (National Research Council)H-Index: 19
#2Francesca NazioH-Index: 1
Last. Sara Marinelli (National Research Council)H-Index: 14
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There is a growing interest on the role of autophagy in diabetes pathophysiology, where development of neuropathy is one of the most frequent comorbidities. We have previously demonstrated that neuropathic pain after nerve damage is exacerbated in autophagy-defective heterozygous Ambra1 mice. Here, we show the existence of a prediabetic state in Ambra1 mice, characterized by hyperglycemia, intolerance to glucose and insulin resistance. Thus, we further investigate the hypothesis that prediabetes...
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#1Arishya Sharma (Cleveland Clinic)H-Index: 6
#2Turkeya Alswillah (CSU: Cleveland State University)H-Index: 1
Last. Alexandru Almasan (Cleveland Clinic)H-Index: 36
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ABSTRACTRecent reports have made important revelations, uncovering direct regulation of DNA damage response (DDR)-associated proteins and chromatin ubiquitination (Ubn) by macroautophagy/autophagy. Here, we report a previously unexplored connection between autophagy and DDR, via a deubiquitnase (DUB), USP14. Loss of autophagy in prostate cancer cells led to unrepaired DNA double-strand breaks (DSBs) as indicated by persistent ionizing radiation (IR)-induced foci (IRIF) formation for γH2AFX, and ...
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#1Rui Chen (Jiangsu University)H-Index: 4
#2Meiping Jiang (Jiangsu University)H-Index: 2
Last. Jinchuan Yan (Jiangsu University)H-Index: 8
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Autophagy is a recycling process that degrades damaged or unneeded cellular components for renewal. Accumulating evidence suggests that dysregulation of autophagy is involved in pulmonary hypertension (PH). PH is a progressive disease characterized by persistent proliferation of apoptosis-resistant pulmonary vascular cells. However, reports on the role of autophagy in the development of PH are often conflicting. In this review, we discuss recent development in the field with emphasis on pulmonar...
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