AMPKα2 Protects Against the Development of Heart Failure by Enhancing Mitophagy via PINK1 Phosphorylation

Mitochondrial dysfunction plays an important role in heart failure (HF). However, the molecular mechanisms regulating mitochondrial functions via selective mitochondrial autophagy (mitophagy) are poorly understood.We sought to determine the role of AMPK (AMP-activated protein kinase) in selective mitophagy during HF.An isoform shift from AMPKα2 to AMPKα1 was observed in failing heart samples from HF patients and transverse aortic...