Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss
Abstract
Microbial metabolites are known to modulate immune responses of the host. The main metabolites derived from microbial fermentation of dietary fibers in the intestine, short-chain fatty acids (SCFA), affect local and systemic immune functions. Here we show that SCFA are regulators of osteoclast metabolism and bone mass in vivo. Treatment of mice with SCFA as well as feeding with a high-fiber diet significantly increases bone mass and prevents...
Paper Details
Title
Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss
Published Date
Jan 4, 2018
Journal
Volume
9
Issue
1
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