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Efficacy of Lactobacillus reuteri DSM 17938 for infantile colic: Systematic review with network meta-analysis

Published on Dec 1, 2017in Medicine1.87
· DOI :10.1097/MD.0000000000009375
Pedro Gutiérrez-Castrellón15
Estimated H-index: 15
,
Flavia Indrio1
Estimated H-index: 1
+ 3 AuthorsGabriel López-Velázquez13
Estimated H-index: 13
Abstract
AbstractBackground:5% to 40% of infants cry excessively, usually accompanied by fussiness and excessive of gas. There are no uniform criteria for treatment of infantile colic. Lactobacillus reuteri DSM 17938 has been used with promising results. The objective of this network-meta-analysis (NMA) is t
  • References (64)
  • Citations (11)
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References64
Newest
#1Brian Hutton (Ottawa Hospital Research Institute)H-Index: 49
#2Georgia Salanti (UoI: University of Ioannina)H-Index: 53
Last. David Moher (Ottawa Hospital Research Institute)H-Index: 100
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The PRISMA statement is a reporting guideline designed to improve the completeness of reporting of systematic reviews and meta-analyses. Authors have used this guideline worldwide to prepare their reviews for publication. In the past, these reports typically compared 2 treatment alternatives. With the evolution of systematic reviews that compare multiple treatments, some of them only indirectly, authors face novel challenges for conducting and reporting their reviews. This extension of the PRISM...
741 CitationsSource
#1Guo-Lin Mi (SDU: Shandong University)H-Index: 1
#2Lei Zhao (Boston Children's Hospital)H-Index: 1
Last. Jin-Ke Xu (CDC: Centers for Disease Control and Prevention)H-Index: 1
view all 6 authors...
Infant colic, excessive crying of unknown cause, is a major burden to families and effects about 10–30 % of infants. Despite decades of research, the exact cause and treatment of infant colic has remained elusive. The use of Lactobacillus reuteri (DSM 17938) in infant colic is somewhat controversial and hence, we designed this study to evaluate its efficacy in infantile colic. We recruited predominantly or exclusively breastfed infants, aged less than 4 months in a placebo controlled observation...
35 CitationsSource
#1Kim Chau (U of T: University of Toronto)H-Index: 3
#2Eddy Lau (U of T: University of Toronto)H-Index: 2
Last. Gideon KorenH-Index: 79
view all 7 authors...
Objective To investigate the effectiveness of Lactobacillus reuteri DSM 17938 for the treatment of infantile colic in breastfed Canadian infants, compared with placebo. Study design A randomized, double-blind, placebo-controlled trial was conducted involving 52 infants with colic, according to modified Wessel criteria, who were assigned at random to receive L reuteri DSM 17938 (10 8 colony-forming units) (n = 24) or placebo (n = 28) for 21 days. Daily crying and fussing times were recorded in a ...
68 CitationsSource
Infant colic (IC), with an estimated prevalence of 5% to 25%, has a high impact on health care costs. Furthermore, reported negative sequelae are disturbed parent-infant interaction, increased susceptibility to abdominal pain, and even child abuse. Its etiology remains unknown, leading to a wide variety in interventions. We hypothesize that definitions and outcome measures in studies on IC will be heterogeneous as well. Our objective is to systematically assess how definitions and outcome measur...
20 CitationsSource
#1Sung (University of Melbourne)H-Index: 1
#2Harriet Hiscock (University of Melbourne)H-Index: 34
Last. Melissa Wake (University of Melbourne)H-Index: 59
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#1Flavia Indrio (University of Bari)H-Index: 28
#2A. Di Mauro (University of Bari)H-Index: 12
Last. Ruggiero Francavilla (University of Bari)H-Index: 44
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IMPORTANCE Infantile colic, gastroesophageal reflux, and constipation are the most common functional gastrointestinal disorders that lead to referral to a pediatrician during the first 6 months of life and are often responsible for hospitalization, feeding changes, use of drugs, parental anxiety, and loss of parental working days with relevant social consequences. OBJECTIVE To investigate whether oral supplementation with Lactobacillus reuteri DSM 17938 during the first 3 months of life can redu...
97 CitationsSource
#1Holgeir Skjeie (University of Oslo)H-Index: 4
#2Trygve Skonnord (University of Oslo)H-Index: 4
Last. Mette Brekke (University of Oslo)H-Index: 20
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Objective . Infantile colic is a painful condition in the fi rst months of infancy. Acupuncture is used in Scandinavia as a treatment for infantile colic. A randomized controlled trial was carried out with the aim of testing the hypothesis that acupuncture treatment has a clinically relevant effect for this condition. Design . A prospective, blinding-validated, randomized controlled multicentre trial in general practice. Research assistants and parents were blinded. Setting . 13 GPs ’ offi ces i...
27 CitationsSource
#1Jasim AnabreesH-Index: 4
#2Flavia Indrio (University of Bari)H-Index: 28
Last. Khalid AlFaleh (KSU: King Saud University)H-Index: 9
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Background Infantile colic is a common paediatric condition which causes significant parental distress. Increased intestinal coliform colonization in addition to alteration in Lactobacillus abundance and distribution may play an important role in its pathogenesis. The objectives of this systematic review are to evaluate the efficacy of probiotic supplementation in the reduction of crying time and successful treatment of infantile colic.
55 CitationsSource
#1Carolina de Weerth (Radboud University Nijmegen)H-Index: 32
#2Susana Fuentes (WUR: Wageningen University and Research Centre)H-Index: 26
Last. W.M. de Vos (UH: University of Helsinki)H-Index: 134
view all 3 authors...
Up to around a quarter of all infants cry excessively and unsoothably during their first months of life. This phenomenon has been termed “infant colic.” In most cases, physicians are unable to determine the cause of the colicky behavior. In a recent study, and by means of comprehensive and deep analyses of more than 1000 intestinal phylotypes, we found that infants with colic showed lower microbiota diversity and stability than control infants in the first weeks of life. Colic-control difference...
38 CitationsSource
ABSTRACTBackground and Aim:Many mothers consult physicians because of frequent infant regurgitation. Guidelines recommend reassurance and dietary treatment as first approaches. The aim of the present study was to test and compare the efficacy of 2 antiregurgitation formulae (ARF).Methods:A prospecti
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Cited By11
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#1Julie EllwoodH-Index: 1
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Objective To conduct a systematic review of systematic reviews and national guidelines to assess the effectiveness of four treatment approaches (manual therapy, probiotics, proton pump inhibitors and simethicone) on colic symptoms including infant crying time, sleep distress and adverse events. Methods We searched PubMed, Embase, Cochrane and Mantis for studies published between 2009 and 2019. Inclusion criteria were systematic reviews and guidelines that used evidence and expert panel opinion. ...
Source
Objective: Chronic functional constipation is a frequent condition. The aim of the study was to evaluate the efficacy of the probiotic Lactobacillus (L.) reuteri DSM 17938 and magnesium oxide (MgO) for relieving chronic functional constipation in children. Study design: A prospective, double-blind, placebo-controlled, randomized, and parallel-group trial was conducted in five pediatric outpatient clinics in Japan. Sixty patients who were more than six months old and under six years of age with a...
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#1Rachel Perry (University Hospitals Bristol NHS Foundation Trust)H-Index: 19
#2Verity Leach (St Mary's Hospital)H-Index: 3
Last. Philippa Davies (UoB: University of Bristol)H-Index: 14
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Infantile colic is a distressing condition characterised by excessive crying in the first few months of life. The aim of this research was to update the synthesis of evidence of complementary and alternative medicine (CAM) research literature on infantile colic and establish what evidence is currently available. Medline, Embase and AMED (via Ovid), Web of Science and Central via Cochrane library were searched from their inception to September 2018. Google Scholar and OpenGrey were searched for g...
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#1Lukas SchwingshacklH-Index: 33
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#1Harald Brüssow (Katholieke Universiteit Leuven)H-Index: 3
Probiotics have been explored in an exponentially increasing number of clinical trials for their health effects. Drawing conclusions from the published literature for the medical practitioner is difficult since rarely more than two clinical trials were conducted with the same probiotic strain against the same medical condition. Consequently, the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) made a few recommendations restricting it to probiotic use against ...
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Maria is a 1.5-month-old healthy baby born at 39 weeks, mainly breastfed, although she has been fed artificial formula on a few occasions. In the last 2 weeks, she has been brought to the clinic with episodes of intense crying which last from 3 to 5 hours/day and occur 4–5 times a week. Her parents are finding it hard to soothe and calm her during these episodes, and find it very distressing. She undergoes a normal clinical examination and there do not seem to be any other associated conditions....
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#1M. Kołodziej (Medical University of Warsaw)H-Index: 1
#2H. Szajewska (Medical University of Warsaw)H-Index: 1
Abstract Objectives To assess the effectiveness of Lactobacillus reuteri DSM 17938 for the prevention of diarrhoea and antibiotic-associated diarrhoea (AAD) in children. Methods Hospitalized children who received antibiotics were assigned by a computer-generated list to receive L. reuteri (at 2 × 108 CFU) or placebo, twice daily, for the duration of antibiotic treatment. Follow up was for 1 week after antibiotic cessation. The primary outcome measures were diarrhoea and AAD. Both were defined ac...
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Probiotics are living microorganisms that confer a health benefit when administered in adequate amounts. It has been speculated that probiotics supplementation during pregnancy and in the neonatal period might reduce some maternal and neonatal adverse outcomes. In this narrative review, we describe the rationale behind probiotic supplementation and its possible role in preventing preterm delivery, perinatal infections, functional gastrointestinal diseases, and atopic disorders during early life.
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Probiotics have been used to ameliorate gastrointestinal symptoms since ancient times. Over the past 40 years, probiotics have been shown to impact the immune system, both in vivo and in vitro. This interaction is linked to gut microbes, their polysaccharide antigens, and key metabolites produced by these bacteria. At least four metabolic pathways have been implicated in mechanistic studies of probiotics, based on mechanistic studies in animal models. Microbial–immune system crosstalk has been l...
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#1Siel Daelemans (Vrije Universiteit Brussel)H-Index: 1
#2Linde Peeters (Vrije Universiteit Brussel)H-Index: 1
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A newborn brings joy to the family. Crying belongs to the spectrum of normal behaviour of young infants. However, although it occurs in about 20% of all infants, unsoothable and persistent crying in young infants distresses the family, although it is usually benign. The aetiology of infantile colic remains unknown, although an unbalanced gastro-intestinal microbiome, increased intestinal permeability, and chronic inflammation are involved, as well as behavioural factors, including over- and unde...
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