Senescence-associated reprogramming promotes cancer stemness
Abstract
Cellular senescence is a stress-responsive cell-cycle arrest program that terminates the further expansion of (pre-)malignant cells. Key signalling components of the senescence machinery, such as p16INK4a, p21CIP1 and p53, as well as trimethylation of lysine 9 at histone H3 (H3K9me3), also operate as critical regulators of stem-cell functions (which are collectively termed 'stemness'). In cancer cells, a gain of stemness may have profound...
Paper Details
Title
Senescence-associated reprogramming promotes cancer stemness
Published Date
Dec 20, 2017
Journal
Volume
553
Issue
7686
Pages
96 - 100
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