Original paper
Conserved non-AUG uORFs revealed by a novel regression analysis of ribosome profiling data
Abstract
Upstream open reading frames (uORFs), located in transcript leaders (5' UTRs), are potent cis-acting regulators of translation and mRNA turnover. Recent genome-wide ribosome profiling studies suggest that thousands of uORFs initiate with non-AUG start codons. Although intriguing, these non-AUG uORF predictions have been made without statistical control or validation; thus, the importance of these elements remains to be demonstrated. To address...
Paper Details
Title
Conserved non-AUG uORFs revealed by a novel regression analysis of ribosome profiling data
Published Date
Dec 18, 2017
Journal
Volume
28
Issue
2
Pages
214 - 222
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Notes
History