Unexpected phenotypic effects of a transgene integration causing a knockout of the endogenous Contactin-5 gene in mice
Abstract
Contactins (Cntn1-6) are a family of neuronal membrane proteins expressed in the brain. They are required for establishing cell-to-cell contacts between neurons and for the growth and maturation of the axons. In humans, structural genomic variations in the Contactin genes are implicated in neurodevelopmental disorders. In addition, population genetic studies associate Contactins loci with obesity and hypertension. Cntn5 knockout mice were first...
Paper Details
Title
Unexpected phenotypic effects of a transgene integration causing a knockout of the endogenous Contactin-5 gene in mice
Published Date
Dec 20, 2017
Journal
Volume
27
Issue
1
Pages
1 - 13
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