Review paper
ZAP-70 in Signaling, Biology, and Disease
Abstract
T cells possess an array of functional capabilities important for host defense against pathogens and tumors. T cell effector functions require the T cell antigen receptor (TCR). The TCR has no intrinsic enzymatic activity, and thus signal transduction from the receptor relies on additional signaling molecules. One such molecule is the cytoplasmic tyrosine kinase ZAP-70, which associates with the TCR complex and is required for initiating the...
Paper Details
Title
ZAP-70 in Signaling, Biology, and Disease
Published Date
Apr 26, 2018
Journal
Volume
36
Issue
1
Pages
127 - 156
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