Analysis of the genomic landscape of multiple myeloma highlights novel prognostic markers and disease subgroups
Abstract
In multiple myeloma, next-generation sequencing (NGS) has expanded our knowledge of genomic lesions, and highlighted a dynamic and heterogeneous composition of the tumor. Here we used NGS to characterize the genomic landscape of 418 multiple myeloma cases at diagnosis and correlate this with prognosis and classification. Translocations and copy number abnormalities (CNAs) had a preponderant contribution over gene mutations in defining the...
Paper Details
Title
Analysis of the genomic landscape of multiple myeloma highlights novel prognostic markers and disease subgroups
Published Date
May 22, 2018
Journal
Volume
32
Issue
12
Pages
2604 - 2616
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